This page is optimized for a taller screen. Please rotate your device or increase the size of your browser window.

Antibody Response to Influenza A(H1N1)pdm09 Among Healthcare Personnel Receiving Trivalent Inactivated Vaccine: Effect of Prior Monovalent Inactivated Vaccine

Manjusha Gaglani, Sarah Spencer, Sarah Ball, Juhee Song, Allison Naleway, Emily Henkle, Sam Bozeman, Sue Reynolds, Wendy Sessions, Kathy Hancock and Mark Thompson


July 7, 2014
Few data are available on the immunogenicity of repeated annual doses of influenza A(H1N1)pdm09-containing vaccines.

We enrolled healthcare personnel (HCP) in direct patient care during the autumn of 2010 at 2 centers with voluntary immunization. We verified the receipt of A(H1N1)pdm09-containing monovalent inactivated influenza vaccine (MIIV) and 2010–2011 trivalent inactivated vaccine (TIV). We performed hemagglutination inhibition antibody (HI) assays on preseason, post-TIV, and end-of-season serum samples. We compared the proportion of HCPs with HI titer ≥40 against A(H1N1)pdm09 per receipt of prior-season MIIV, current-season TIV, both, or neither.

HCP immunization programs should consider effects of host immune response and vaccine antigenic distance on immunogenicity of repeated annual doses of influenza vaccines.