The Caribbean region has the second highest HIV/AIDS prevalence in the world. Despite steadily increasing wealth classifications in the region, government resources are scarce and most national HIV programs rely heavily on external funding for program implementation. Given the likelihood of declining donor funding, efforts to expand local resource mobilization, including from the private sector, are warranted. Understanding the current and potential role of the private sector in addressing health needs is critical to maximizing the full potential of national HIV responses. PEPFAR is supporting this work as articulated in the US-Caribbean Regional HIV and AIDS Partnership Framework 2010-2014.