The Health Profession Opportunity Grants (HPOG) Program provides education and training to Temporary Assistance for Needy Families recipients and other low-income individuals for high-demand occupations in healthcare. The goal is to enable participants to build a career by advancing through successively higher levels of education and training. In this three-year impacts report, 42 HPOG programs saw gains in training completion, healthcare employment, and career progress, but no significant rise in earnings.